Computational Science

Professor Jacqueline Dresch

Jacqueline Dresch, Ph.D.

Assistant Professor
Department of Mathematics and Computer Science
Clark University
Worcester, MA 01610-1477

Phone: (508) 793-7346
Email: jdresch@clarku.edu

Research Website


Education

Jackie Dresch received a B.A from SUNY Geneseo in 2006, and a Ph.D. in Mathematics and Quantitative Biology from Michigan State University in 2012.  She has been at Clark since 2015.

Current Research and Teaching

Professor Dresch’s research focuses on modeling transcriptional regulation in fruit flies (Drosophila melanogaster).  She is interested in many topics at the interface of mathematics and biology, including reaction-diffusion equations, numerical solvers, sensitivity analysis, parameter estimation, image processing, and bioinformatics.

Professor Dresch enjoys teaching a wide range of Mathematics courses, including Calculus, Linear Algebra, Differential Equations, Numerical Analysis, and Mathematical Biology.

Selected Publications

McCarthy GD, Drewell RA, Dresch JM (2015) Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos. PeerJ 3:e1022 https://dx.doi.org/10.7717/peerj.1022
 
Zellers RG, Drewell RA, Dresch JM (2015) MARZ: An algorithm to combinatorially analyze gapped n-mer models of transcription factor binding. BMC Bioinformatics. 16: 30.
 
Drewell RA, Nevarez MJ, Kurata JS, Winkler LN, Li L, Dresch JM (2014) Deciphering the combinatorial architecture of a Drosophila homeotic gene enhancer. Mechanisms of Development. 131:68-77.
 
Suleimenov Y, Ay A, Samee MA, Dresch JM, Sinha S, Arnosti DN (2013) Global parameter estimation for thermodynamic models of transcriptional regulation. Methods. 62(1):99-108.
 
Dresch JM, Richards M, Ay A (2013) A Primer on Thermodynamic-based Models for Deciphering Transcriptional Regulatory Logic. BBA – Gene Regulatory Mechanisms. 1829(9):946-53.
 
Dresch JM, Thompson MA, Arnosti DN, Chiu C (2013) Two-Layer Mathematical Modeling of Gene Expression: Incorporating DNA-level Information and System Dynamics. SIAM Journal of Applied Mathematics 73(2): 804-826.
 
Dresch JM and Drewell RA (2012) Decoding the cis-regulatory grammar behind enhancer architecture. Genomics III: Methods, Techniques and Applications (iConcepts Press, book chapter) ISBN: 978-1-922227-096.

Pettie KP, Dresch JM, Drewell RA (2016) Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks. Mechanisms of Development. DOI: 10.1016/j.mod.2016.06.001.

Dresch JM, Zellers RG, Bork DK and Drewell RA (2016) Nucleotide interdependency in transcription factor binding sites in the Drosophila genome. Gene Regulation and Systems Biology. 10:21-33.

*Sayal R, *Dresch JM, Pushel I, Taylor BR, Arnosti DN (2016) Quantitative perturbation-based analysis of gene expression in early Drosophila embryo. eLife 5:e08445 (* – equal contribution)

Dresch, JM, Arnosti DN (2015) The Wisdom of Crowds: Can Mathematical Models Crack the cis Regulatory Code? Cell Systems 1(6):379–380