Cytokinesis, the process by which a cell constricts at the equator to
ultimately divide into two daughter cells remains poorly understood.
The primary interest of this lab has been to identify the proteins/genes
involved in both the mechanics and the regulation of this process. To
achieve this goal the lab uses the cellular slime mold Dictyostelium
discoideum. Using Dictyostelium, a molecular genetic screen was
developed to identify the genes required for cytokinesis. Several genes
were subsequently identified and we are in the process of describing how
these genes participate in the regulation of cytokinesis. Future work will
include further characterization of these genes, as well as continuation of
the screen to identify additional genes involved in cytokinesis.