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Jackie Dresch received a B.A from SUNY Geneseo in 2006, and a Ph.D. in Mathematics and Quantitative Biology from Michigan State University in 2012. She has been at Clark since 2015.
Professor Dresch’s research focuses on modeling transcriptional regulation in fruit flies (Drosophila melanogaster). She is interested in many topics at the interface of mathematics and biology, including reaction-diffusion equations, numerical solvers, sensitivity analysis, parameter estimation, image processing, and bioinformatics.
Professor Dresch enjoys teaching a wide range of Mathematics courses, including Calculus, Linear Algebra, Differential Equations, Numerical Analysis, and Mathematical Biology.
Degrees
- Ph.D. in Mathematics and Quantitative Biology, Michigan State University, 2012
- B.S. in Mathematics, SUNY Geneseo, 2006
Affiliated Department(s)
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Scholarly and Creative Works
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Improving bioinformatic tools using protein-DNA binding data
Joint Mathematics Meetings
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Hynes Convention Center, Boston, MA
January
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2023
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The Dictyostelium discoideum genome lacks significant DNA methylation and uncovers palindromic sequences as a source of false positives in bisulfite sequencing
Published in NAR Genomics and Bioinformatics
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2023
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Transcriptome profile in Drosophila Kc and S2 embryonic cell lines.
Published in G3: Genes|Genomes|Genetics
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2023
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Published in Mathematical Biosciences
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2021
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Getting the most out of an interdisciplinary undergraduate research experience
Gryphon and Pleiades Honors Society Seminar Series
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Clark University
April
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2019
Sponsored by Gryphon and Pleiades Honors Society
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Rapid and efficient purification of Drosophila homeodomain transcription factors for biophysical characterization
Published in Protein expression and purification
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2019
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Vol. 158
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Analyzing the stability of gene expression using a simple reaction-diffusion model in an early Drosophila embryo
Published in Mathematical biosciences
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2019
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Vol. 316
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Biophysical and structural analysis of Antennapedia and Ultrabithorax homeodomain transcription factor-DNA binding affinities
Protein Science●
2019
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Vol. 28
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Biophysical and structural analysis of Drosophila transcription factors
Next-in-BIO 2018
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Worcester MA
November
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2018
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Whole genome bisulfite sequencing reveals a sparse, but robust pattern of DNA methylation in the Dictyostelium discoideum genome
Published in BIORXIV
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2017
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The folded k-spectrum kernel: A machine learning approach to detecting transcription factor binding sites with gapped nucleotide dependencies
Published in PloS one
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2017
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Vol. 12
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Issue #10
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Quantitative perturbation-based analysis of gene expression predicts enhancer activity in early Drosophila embryo
Published in eLife
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2016
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Vol. 5
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Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks
Published in Mechanisms of development
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2016
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Vol. 141
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Nucleotide Interdependency in Transcription Factor Binding Sites in the Drosophila Genome
Published in Gene regulation and systems biology
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2016
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Vol. 10
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MARZ: an algorithm to combinatorially analyze gapped n-mer models of transcription factor binding
Published in BMC bioinformatics
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2015
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Vol. 16
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The Wisdom of Crowds: Can Mathematical Models Crack the cis Regulatory Code?
Published in Cell systems
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2015
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Vol. 1
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Issue #6
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Global sensitivity analysis of a dynamic model for gene expression in Drosophila embryos
Published in PeerJ
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2015
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Vol. 3
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Deciphering the combinatorial architecture of a Drosophila homeotic gene enhancer
Published in Mechanisms of development
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2014
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Vol. 131
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Global parameter estimation for thermodynamic models of transcriptional regulation
Published in Methods (San Diego, Calif.)
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2013
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Vol. 62
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Issue #1
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Flanking sequence context-dependent transcription factor binding in early Drosophila development
Published in BMC bioinformatics
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2013
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Vol. 14
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TWO-LAYER MATHEMATICAL MODELING OF GENE EXPRESSION: INCORPORATING DNA-LEVEL INFORMATION AND SYSTEM DYNAMICS
Published in SIAM journal on applied mathematics
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2013
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Vol. 73
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Issue #2
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A primer on thermodynamic-based models for deciphering transcriptional regulatory logic
Published in Biochimica et biophysica acta
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2013
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Vol. 1829
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Issue #9
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Thermodynamic modeling of transcription: sensitivity analysis differentiates biological mechanism from mathematical model-induced effects
Published in BMC systems biology
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2010
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Vol. 4
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Network structure, and vaccination strategy and effort interact to affect the dynamics of influenza epidemics
Published in Journal of theoretical biology
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2007
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Vol. 246
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Issue #2
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Precise measurements of protein-DNA binding affinities support the use of PWM-based approaches in modeling transcriptional regulation
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Multiple enhancers regulate twin of eyeless expression during early Drosophila development
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Investigating the sequence landscape in the Drosophila Initiator core promoter element using an enhanced MARZ algorithm
Published in PeerJ
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Awards & Grants
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Investigating the molecular mechanisms of transcriptional regulation at Drosophila homeotic genes
National Institutes of Health
May. 1, 2020 - Apr. 30, 2023
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Investigating the nature of TF-DNA interactions through biophysical measurements, bioinformatics, and synthetic biology
Faculty Development Funds (Larry Fechter and Thomas Macke Stansbury)
Jun. 1, 2020 - May. 31, 2021
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Decoding cis-regulatory grammar at Hox genes
National Institutes of Health
Apr. 1, 2016 - Mar. 31, 2020
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