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Sharon Huo graduated from Peking University in 1990, majoring in Applied Chemistry. After working at the Institute of Chemistry, Chinese Academy of Sciences for four years, she started her Ph.D. study at Boston University, followed by post-doctoral training at UC-San Francisco. She joined the faculty of Clark University in 2001 as a tenure-track Assistant Professor and was promoted to full professor in 2015. Her research is in the field of computational biophysics. She studies protein folding/misfolding/aggregation, protein conformational changes related signal transduction, and protein-ligand interaction using computational approaches. Her research was supported by NIH R15 and R01 as well as private agents. She has established herself in the field of studying amyloidogenic proteins. In recent years, one of her research foci is to develop analysis methods to extract kinetic information from a large number of protein conformations obtained in molecular dynamics simulations. The analysis methods developed in her group include the MaxFlux reaction-path algorithm combined with the probabilistic roadmap motion planning method, graph representation of protein free energy landscape, and diffusion maps with a hybrid geometry energy-based kernel.
Selected peer-reviewed publications:
Tan, Q., Duan, M,. Li, M., Han, Li., and Huo, S. (2019) Approximating dynamic proximity with a hybrid geometry energy-based kernel for diffusion maps. J. Chem. Phys. 151, 105101.
Duan, M., Liu, H., Li, M., and Huo, S. (2015) Network representation of conformational transitions between hidden intermediates of Rd-apocytochrome b562. J. Chem. Phys. 143, 135101.
Li, M., Duan, M., Fan, J., Han, L., and Huo, S. (2013) Graph representation of protein free energy landscape. J. Chem. Phys. 139: 185101.
Duan, M., Fan, J., and Huo, S. (2012) Conformations of islet amyloid polypeptide monomers in a membrane environment: Implications for fibril formation. PLoS ONE 7(11): e47150.
Degrees
- Ph.D. in Computational Chemistry, Boston University, 1999
- B.S. in Chemistry, Peking University, 1990
Affiliated Department(s)
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Scholarly and Creative Works
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Allosteric signal propagation pathways of unphosphorylated RING-type E3 ubiquitin ligase c-Cbl
ACS (American Chemical Society) Annual Meeting, Fall 2022
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Chicago, IL
August
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2022
Sponsored by ACS
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Contrasting solution-state properties within a family of amyloidbinding molecular tools
Published in Tetrahedron
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2022
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Interplay between Human Islet Amyloid Polypeptide Aggregates and Microhetergeneous Membranes
Published in BBA-Biomembrane
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2021
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Approximating dynamic proximity with a hybrid geometry energy-based kernel for diffusion maps
Published in The Journal of chemical physics
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2019
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Vol. 151
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Issue #10
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Awards & Grants
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Capturing the yin and yang of neuroinflammation through novel PET ligands
NIH
Jun. 1, 2021 - May. 31, 2024
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PET imaging to detect the yin and yang of neuroinflammation
Alzheimer’s Association
Nov. 30, 2020 - Nov. 30, 2023
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