Faculty Biography

Charles Jakobsche

Charles Jakobsche, Ph.D.

Organic Chemistry, Chemical Biology, Chemistry of Medicine

Assistant Professor
Carlson School of Chemistry and Biochemistry
Clark University
Worcester, MA 01610-1477

Phone: 508-793-8866
Email: cjakobsche@clarku.edu

Curriculum Vitae
Research Lab Website


Postdoctoral Fellow, Yale University, 2009-2012
Ph.D. Yale University, 2009
B.A. Williams College, 2004

Current Research Interests

Professor Jakobsche brings a wide range of interests and expertise to his research. The group's research projects typically embody the following major themes:

  1. Using synthetic organic chemistry to make target molecules, whether they are structures derived from natural products or artificial compounds created through rational design
  2. Designing functional probe molecules that have well defined interactions with particular proteins or other biological structures and that can be used for chemical biology analysis of these systems
  3. Developing new organic chemistry reactions that can help enable more efficient synthesis of target molecules
  4. Performing detailed analysis of reactions or molecular structures to better understand the properties and reactivities of unusual organic molecules
  5. Using chemistry to learn about biological systems that are relevant to diseases, medicines, or the immune system

More details about specific projects can be found on his group's webpage.

Selected Publications

"UsingN-Nitroso-Dichloroacetamides to Conveniently Convert Non-Branched Primary Amines into Alcohols"
N.S. MacArthur, L. Wang, B. G. McCarthy, C. E. Jakobsche
Synthetic Communications 2015 (In Press)

"Overcoming the Inherent Alkylation Selectivity of 2–3-trans-3–4-cis-Trisubstituted Cyclopentanones"
M. B. Reardon, G. W. Carlson, C. E. Jakobsche
Synthesis 2014, 46, 387–393

"Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators"
C. E. Jakobsche, C. G. Parker, R. N. Tao, M. D. Kolesnikova, E. F. Douglass, D. A. Spiegel
ACS Chem. Biol. 2013, 8, 2484–2492

"Reprogramming Urokinase into an Antibody Recruiting Anticancer Agent"
C. E. Jakobsche, P. J. McEnaney, A. X. Zhang, D. A. Spiegel
ACS Chem. Biol. 2012, 7, 316–321

"n→π* Interaction and n)(π Pauli Repulsion Are Antagonistic for Protein Stability"
C. E. Jakobsche, A. Choudhary, S. J. Miller, R. T. Raines
J. Am. Chem. Soc. 2010, 132, 6651–6653.

"Functional Analysis of an Aspartate-Based Epoxidation Catalyst with Amide-to-Alkene Peptidomimeic Catalyst Analogues"
C. E. Jakobsche, G. Peris, S. J. Miller
Angew. Chem., Int. Ed. 2008, 47, 6707–6711

"Aspartate-Catalyzed Asymmetric Epoxidation Reactions"
G. Peris, C. E. Jakobsche, S. J. Miller
J. Am. Chem. Soc. 2007, 129, 8710–8711