The Larochelle Lab
at Clark University
Stephen Burrows
Bio: After graduating from Tri-State University, I began my scientific career at Indiana University in Indianapolis as a Research Assistant and would later move on to Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan. Working in both Cardiovascular and Atherosclerosis departments primarily in enzymology, lipid chemistry, and animal disease models. While at Park-Davis I completed a Masters program at Eastern Michigan University in Biology. Later moving to G.D. Searle Cardiovascular Disease Research, then on to SmithKline Beecham Pharmaceuticals/Animal Health in the Department of Protein Biochemistry where I began working in recombinant protein chemistry. My career then moved into the area of biotechnology and biopharmaceuticals. This included not only research but also development and manufacturing covering many areas including vaccines, enzymes, and therapeutic proteins. In 2001 a position with a local company brought me to the Worcester area and in early 2003 I joined the Larochelle lab.
Research interests: My research interest and area of study is cellular adhesion and interaction of the molecules which control this process.
More about me : Avid hunter, fisherman, motorcyclist and woodworking are a part of any free time.
Papers: Biological and Biophysical Characterization of Recombinant Soluble Human E-Selectin Purified at Large Scale by Reversed-Phase High-Performance Liquid Chromatography. S.D. Burrows, S.G. Franklin, M.R. Brigham-Burke, I.S. Brooks, D.E. McNulty, J.A. Feild, K. Anumula and D.J. O’Shannessy, Departments of Protein Biochemistry, Macromolecular Sciences, Cellular Biochemistry and Analytical Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939. Journal of Chromatography B, 668 (1995) 219-231.
Wild-Type Interleukin-8 is a Monomer at Physiological Concentrations: Implications for its Biological Activity. S.D. Burrows, M.L. Doyle, K.P. Murphy, S.G. Franklin, J.R. White, I. Brooks, D.E. McNulty, M.O. Scott, J.R. Knutson, D. Porter, P.R. Young and P.Hensley, Departments of Macromolecular Sciences, Protein Biochemistry, Molecular Immunology, and Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, and Laboratory of Cellular Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892. Biochemistry, 33:12741-5, 1994.
Method for the Purification and Determination of Molecular Weights of Three Type I Cyclic 3’,5’-Nucleotide Phosphodiesterases./ Stephen D. Burrows. Eastern Michigan University, Ypsilanti, MI 48197. Masters Abstracts International, 28, 1990.
Protection of the Failing Heart: Effects of Chronic Administration of Diltiazem and Digitalis on Myocardial Metabolism in the Cardiomyopathic Hamster. R.E.Weishaar, S.D. Burrows, S.N. Kim, D.C. Kobylarz-Singer, L.K. Andrews, M. M. Quade, R. Overhiser and H.R. Kaplan. Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105. Journal of Applied Cardiology 2:339-360, 1987.
Multiple Molecular Forms of Cyclic Nucleotide Phosphodiesterase in Cardiac and Smooth Muscle and in Platelets: Isolation, Characterization, and Effects of Various Reference Phosphodiesterase Inhibitors and Cardiotonic Agents. Ronald E. Weishaar, Stephen D. Burrows, Diane C. Kobylarz, Mary M. Quade and Dale B. Evans. Warner-Lambert/ Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105. Biochemical Pharmacology 35:787-800, 1 March 1986
Abstracts: Track protein expression and purification visually with RedSee™ from Blue Sky Biotech. Scott Gridley, Weijun Ma, Stephen D. Burrows, Denis G. Kole, Norman Y. Garceau and Paul A. Wengender Blue Sky Biotech, Inc., 25 Winthrop Street, Worcester, MA 01604.
Label-Free Screening of Stearoyl-Coenzyme A Desaturase from an Enriched Rat Liver Fraction. Scott Gridley, Stephen Burrows, Norman Garceau, and Paul Wengender; Blue Sky Biotech, Inc., 25 Winthrop St., Worcester, MA 01604; William A. LaMarr and Can C. Özbal; BioTrove Inc., 12 Gill St., Suite 4000, Woburn, MA 01801, SBS 12th Annual Conference, 17th-21st September, 2006.
Label-Free Screening of Acetyl-CoA Carboxylase from an Enriched Rat Liver Fraction. William A. LaMarr and Can C. Özbal; BioTrove Inc., 12 Gill St., Suite 4000, Woburn, MA 01801; Stephen Burrows and Paul Wengender; Blue Sky Biotech, Inc., 25 Winthrop St., Worcester, MA 01604, SBS 12th Annual Conference, 17th-21st September, 2006.
Wild-Type Interleukin-8 is a Monomer at Physiological Concentrations: Implications for its Biological Activity. Stephen D. Burrows, Michael L. Doyle, Kenneth P. Murphy, Samuel G. Franklin, John R. White, Ian Brooks, Dean E. McNulty, Miller Scott, Jay Knutson, Denise Porter, Peter R. Young, Preston Hensley. SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939, University of Iowa, Iowa City, Iowa 52242 and NHLBI, LCB, NIH, Bethesda, Maryland 20892, Protein Society Meeting July 11, 1994.
Purification and Characterization of Interleukin-8 (IL-8): Demonstration of Dimer Dissociation. Stephen D. Burrows, Preston Hensley, Samuel G. Franklin, John R. White, Michael L. Doyle, Ian Brooks, Dean E. McNulty, Miller Scott, Jay Knutson, Denise Porter and Peter R. Young. SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939 and NHLBI, LCB, NIH, Bethesda, Maryland 20892, ASBMB, May 21-25, 1994.
Method for the Purification and Determination of Molecular Weights of Three Type I Cyclic 3’,5’-Nucleotide Phosphodiesterases. Stephen D. Burrows and Paul A. Volz. Eastern Michigan University, Ypsilanti, Michigan 48197. Pharmacologist, August 1988.
The Temporal Relationship Between Cardiovascular Dysfunction and Changes in Atrial Natriuretic Factor (ANF) in the Cardiomyopathic Hamster. R. Weishaar, K. Kieft, D. Bousley, B. Krause, S. Kim, F. Bjork, R. Grekin, S. Burrows and D. Taylor. Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105.
Neutrophil Mediated Modification of LDL: A Role for Myeloperoxidase, J.A. Cornicelli, L.J. Devall, C.S. Sekerke, S.D. Burrows, C.D. Wright, and R.S. Newton. Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105.
Protection of the Failing Heart: Effects of Chronic Administration of Diltiazem and Digitalis on Myocardial Metabolism in the Cardiomyopathic Hamster. S.D. Burrows, R.E. Weishaar, S.N. Kim, D.C. Kobylarz-Singer, L.K. Andrews, M. M. Quade, and H.R. Kaplan. Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michagan 48105. Federation Proceedings 45:689 (Abstract 3103) March 1, 1986.
Effects of CI-914, A Novel Cardiotonic Agent, on Molecular Form of Phosphodiesterase from Ventricular Muscle, Coronary Arteries, and Platelets. M.M. Quade, S.D. Burrows, D.C. Kobylarz, R.E. Weishaar and D.B. Evans. Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105. Pharmacologist, 26,106, 1984.
Ruthenium Red (RR)-Induced Stimulation of Ca2+ Uptake by Junctional Sarcoplasmic Reticulum Vesicles (JSRV) Isolated from Heart. Larry R. Jones and Stephen D. Burrows. Indiana University School of Medicine, Indianapolis, Indiana 46202, ASBC, Abs# 1024, June 5-9, 1983.
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